ABSTRACT
METHODS@#From January 2005 to December 2013, 83 patients with refractory/recurrent CD20@*RESULTS@#All the patient achieved complete response. The median follow.up time was 39 months. Both the two groups collected peripheral blood stem cells successfully, and had no difference in hematopoietic reconstitution time. Three patients in treatment group and six patients in control group relapsed and the three year overall survival and EFS in treatment group was significantly higher than that in control group, that is（93.0% vs 73.1%, P=0.037） and （89.5% vs 65.4%, P=0.034）, respectively. Subgroup analysis showed that: compared with the treatment group in which using R in the whole courses(before and after transplantation, and collection of stem cells) was superior to the control group in both OS and EFS, with the OS 97% vs 87.5% (P>0.05) and EFS 97% vs 76.2% (P=0.05) respectively. While stratified by the different courses of rituximab, the OS was 88.9% (1-2 courses, 9 cases), 93.1% (3-4 courses, 29 cases), 94.7%(more than 5 courses,19 cases), and EFS was 77.8%, 89.7% and 94.7%, respectively.@*CONCLUSION@#For the patients with refractory/recurrent CD20
Subject(s)
Humans , Antineoplastic Combined Chemotherapy Protocols , Disease-Free Survival , Hematopoietic Stem Cell Transplantation , Hodgkin Disease , Lymphoma, Non-Hodgkin/drug therapy , Rituximab/therapeutic use , Transplantation, Autologous , Treatment OutcomeABSTRACT
OBJECTIVE@#To compare the clinical efficacy of femoral head replacement and internal fixation in the treatment of unstable intertrochanteric fractures in the elderly.@*METHODS@#Retrospective analysis of 70 cases of unstable intertrochanteric fractures treated from January 2016 to January 2019 and meeting the inclusion and exclusion criteria, 39 cases were fixed with closed reduction and new proximal femoral intramedullary nail(InterTAN), and 31 cases were treated with open trochanter reconstruction and artificial femoral head replacement. The operation time, intraoperative bleeding, hospital stay, weight bearing time, postoperative complication rate and hip function recovery (Harris score) were compared between two groups.@*RESULTS@#All cases were followed up for 12 to 24 months. There were no significant differences in intraoperative bleeding and hospital stay between the two groups (@*CONCLUSION@#InterTAN and femoral head replacement can treat unstable intertrochanteric fractures in the elderly, but femoral head replacement can move down early, improve the quality of life at the end of life, reduce postoperative complications and facilitate the treatment of coexisting diseases in internal medicine.
Subject(s)
Aged , Humans , Bone Nails , Femoral Fractures , Femur Head , Fracture Fixation, Internal , Fracture Fixation, Intramedullary , Hip Fractures/surgery , Quality of Life , Retrospective Studies , Treatment OutcomeABSTRACT
Objective To evaluate the efficacy and safety of oxygen inhalation combined with oral administration of soy isoflavones on people who migrated from plains to high altitude area suffering from polycythemia. Methods Eighty young men, who migrated to the area of altitude of 3500~5300m for more than ten months, and their hemoglobin (HGB) level was verified in the range of 190g/L≤HGB 0.05). Multiple linear regression analysis revealed that the affecting factors of HGB that the change in HGB values was significantly associated with test grouping. In addition, there were no obvious side effects and changes in BP, ECG, chest X-ray, liver and kidney functions before and after soy isoflavones intake. Conclusion In high-altitude area, oxygen and oral administration of soy isoflavones are safe and more effective measure in the early prevention of high altitude polycythemia.